Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication

Abstract

Phorbol esters (e.g., TPA) activate protein kinase C (PKC), increase connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types. We asked whether PKC directly phosphorylates and regulates Cx43. Rat epithelial T51B cells metabolically labeled with (32)P(i) yielded two-dimensional phosphotryptic maps of Cx43… (More)

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@article{Lampe2000PhosphorylationOC, title={Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication}, author={Paul D. Lampe and Erica M Tenbroek and Janis M Burt and Wendy E. Kurata and Ross G. Johnson and Alan Lau}, journal={The Journal of Cell Biology}, year={2000}, volume={149}, pages={1503 - 1512} }