Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.

  title={Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.},
  author={Hariharan Subramanian and Ren{\'e} Peiman Zahedi and Albert Sickmann and Ulrich Walter and Stepan P Gambaryan},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={11 8},
BACKGROUND Signaling via protein kinase A (PKA) and protein kinase G (PKG) is critical for maintaining platelets in the resting state. Both kinases down-regulate the activity of the small GTPase Rap1b, a critical signaling switch for integrin activation and platelet aggregation. However, the mechanism of Rap1b regulation by PKA and PKG is largely unknown. OBJECTIVE To identify the PKA phosphorylation sites in calcium and diacylglycerol-regulated guanine nucleotide exchange factor I (CalDAG… CONTINUE READING


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