Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock

@article{Gau2002PhosphorylationOC,
  title={Phosphorylation of CREB Ser142 Regulates Light-Induced Phase Shifts of the Circadian Clock},
  author={Daniel Gau and Thomas Lemberger and Charlotte von Gall and Oliver Kretz and Nguyet Le Minh and Peter Gass and Wolfgang Schmid and Ueli Schibler and Horst-Werner Korf and Günther Schütz},
  journal={Neuron},
  year={2002},
  volume={34},
  pages={245-253}
}
Biological rhythms are driven in mammals by a central circadian clock located in the suprachiasmatic nucleus (SCN). Light-induced phase shifting of this clock is correlated with phosphorylation of CREB at Ser133 in the SCN. Here, we characterize phosphorylation of CREB at Ser142 and describe its contribution to the entrainment of the clock. In the SCN, light and glutamate strongly induce CREB Ser142 phosphorylation. To determine the physiological relevance of phosphorylation at Ser142, we… Expand
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