Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

@article{Dutertre2004PhosphorylationOC,
  title={Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.},
  author={St{\'e}phanie Dutertre and Martine Cazales and Muriel Quaranta and Carine Froment and Valerie Trabut and C Dozier and Gladys Mirey and J M Bouche and Nathalie Theis-Febvre and Estelle Schmitt and Bernard Monsarrat and Claude Prigent and Bernard Ducommun},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 12},
  pages={2523-31}
}
Aurora-A protein kinase, which is the product of an oncogene, is required for the assembly of a functional mitotic apparatus and the regulation of cell ploidy. Overexpression of Aurora-A in tumour cells has been correlated with cancer susceptibility and poor prognosis. Aurora-A activity is required for the recruitment of CDK1-cyclin B1 to the centrosome prior to its activation and the commitment of the cell to mitosis. In this report, we demonstrate that the CDC25B phosphatase, an activator of… CONTINUE READING