Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import.

@article{Darovic2015PhosphorylationOC,
  title={Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import.},
  author={Simona Darovic and Sonja Prpar Mihevc and Vera Župunski and Gregor Gun{\vc}ar and Maja {\vS}talekar and Youn-bok Lee and Christopher E Shaw and Boris Rogelj},
  journal={Journal of cell science},
  year={2015},
  volume={128 22},
  pages={
          4151-9
        }
}
Aberrant cytoplasmic aggregation of FUS, which is caused by mutations primarily in the C-terminal nuclear localisation signal, is associated with 3% of cases of familial amyotrophic lateral sclerosis (ALS). FUS aggregates are also pathognomonic for 10% of all frontotemporal lobar degeneration (FTLD) cases; however, these cases are not associated with mutations in the gene encoding FUS. This suggests that there are differences in the mechanisms that drive inclusion formation of FUS in ALS and… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

  • T. J. Kwiatkowski, Jr., +8 authors T Munsat
  • Science
  • 2009
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…