Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

@article{Bassik2004PhosphorylationOB,
  title={Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.},
  author={Michael C Bassik and Luca Scorrano and Scott A. Oakes and Tullio Pozzan and S Stanley J. Korsmeyer},
  journal={The EMBO journal},
  year={2004},
  volume={23 5},
  pages={
          1207-16
        }
}
Phosphorylation of BCL-2 within an unstructured loop inhibits its antiapoptotic effect. We found that phosphorylated BCL-2 predominantly localized to the endoplasmic reticulum (ER) and tested whether phosphorylation would control its activity at this organelle, where Ca(2+) dynamics serve as a critical control point for apoptosis. Phosphorylation greatly inhibits the ability of BCL-2 to lower [Ca(2+)](er) and protect against Ca(2+)-dependent death stimuli. Cells expressing nonphosphorylatable… CONTINUE READING
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