Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis.

@article{Berndtsson2005PhosphorylationOB,
  title={Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis.},
  author={Maria Berndtsson and Yoshiyuki Konishi and Azad Bonni and Maria H{\"a}gg and Maria C. Shoshan and Stig Linder and Aleksandra Mandic Havelka},
  journal={FEBS letters},
  year={2005},
  volume={579 14},
  pages={
          3090-4
        }
}
Phosphorylation of BCL-2 family member BAD at different residues triggers different physiological effects, either inhibiting or promoting apoptosis. The recently identified phosphorylation site at Ser-128 enhances the apoptotic activity of BAD. We here show that BAD becomes phosphorylated at Ser-128 in the mitotic phase of the cell cycle in NIH3T3 cells. We also show that BAD-S128 is phosphorylated in taxol-treated mouse fibroblasts and MDA-MB-231 human breast cancer cells. However, expression… CONTINUE READING
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