Phosphorylation of ATXN1 at Ser776 in the cerebellum.

  title={Phosphorylation of ATXN1 at Ser776 in the cerebellum.},
  author={Nathan D. Jorgensen and J. Michael Andresen and Sara Lagalwar and Ben Armstrong and Sam Stevens and Courtney E Byam and Lisa A. Duvick and Shaojuan Lai and Paymaan Jafar-nejad and Huda Y. Zoghbi and H. Brent Clark and Harry T. Orr},
  journal={Journal of neurochemistry},
  volume={110 2},
Spinocerebellar ataxia type 1 (SCA1) is one of nine inherited neurodegenerative disorders caused by a mutant protein with an expanded polyglutamine tract. Phosphorylation of ataxin-1 (ATXN1) at serine 776 is implicated in SCA1 pathogenesis. Previous studies, utilizing transfected cell lines and a Drosophila photoreceptor model of SCA1, suggest that phosphorylating ATXN1 at S776 renders it less susceptible to degradation. This work also indicated that oncogene from AKR mouse thymoma (Akt… CONTINUE READING


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GPS 2.0, a tool to predict kinase-specific phosphorylation sites in hierarchy.

Molecular & cellular proteomics : MCP • 2008
View 3 Excerpts
Highly Influenced

A promoter that drives transgene expression in cerebellar Purkinje cells and bipolar neurons

J. Oberdick, R J.Smeyne, J R.Mann, S. Zackson, J I.Morgan
Science 248, • 1990
View 3 Excerpts
Highly Influenced

In vitro protein kinase activity measurement by flow cytometry

D J.Bernsteel, D L.Roman, R R.Neubig
Anal. Biochem • 2008

The roles of kinases in familial Parkinson’s disease

M R.Cookson, W. Dauer, +3 authors J. Shen
J. Neurosci • 2007

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