Phosphorylation of ATXN1 at Ser776 in the cerebellum.

@article{Jorgensen2009PhosphorylationOA,
  title={Phosphorylation of ATXN1 at Ser776 in the cerebellum.},
  author={Nathan D. Jorgensen and J. Michael Andresen and Sara Lagalwar and Ben Armstrong and Sam Stevens and Courtney E Byam and Lisa A. Duvick and Shaojuan Lai and Paymaan Jafar-nejad and Huda Y. Zoghbi and H. Brent Clark and Harry T. Orr},
  journal={Journal of neurochemistry},
  year={2009},
  volume={110 2},
  pages={675-86}
}
Spinocerebellar ataxia type 1 (SCA1) is one of nine inherited neurodegenerative disorders caused by a mutant protein with an expanded polyglutamine tract. Phosphorylation of ataxin-1 (ATXN1) at serine 776 is implicated in SCA1 pathogenesis. Previous studies, utilizing transfected cell lines and a Drosophila photoreceptor model of SCA1, suggest that phosphorylating ATXN1 at S776 renders it less susceptible to degradation. This work also indicated that oncogene from AKR mouse thymoma (Akt… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

GPS 2.0, a tool to predict kinase-specific phosphorylation sites in hierarchy.

Molecular & cellular proteomics : MCP • 2008
View 3 Excerpts
Highly Influenced

A promoter that drives transgene expression in cerebellar Purkinje cells and bipolar neurons

J. Oberdick, R J.Smeyne, J R.Mann, S. Zackson, J I.Morgan
Science 248, • 1990
View 3 Excerpts
Highly Influenced

In vitro protein kinase activity measurement by flow cytometry

D J.Bernsteel, D L.Roman, R R.Neubig
Anal. Biochem • 2008

The roles of kinases in familial Parkinson’s disease

M R.Cookson, W. Dauer, +3 authors J. Shen
J. Neurosci • 2007

Similar Papers

Loading similar papers…