Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

@article{Furman1986PhosphorylationO3,
  title={Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.},
  author={Phillip A. Furman and James A. Fyfe and Marty H. St. Clair and Kent J. Weinhold and J. L. Rideout and George Andrew Freeman and Sandra Nusinoff Lehrman and Dani P. Bolognesi and Samuel E. Broder and Hiroaki Mitsuya},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 21},
  pages={
          8333-7
        }
}
  • P. FurmanJ. A. Fyfe H. Mitsuya
  • Published 1 November 1986
  • Biology, Chemistry
  • Proceedings of the National Academy of Sciences of the United States of America
The thymidine analog 3'-azido-3'-deoxythymidine (BW A509U, azidothymidine) can inhibit human immunodeficiency virus (HIV) replication effectively in the 50-500 nM range [Mitsuya, H., Weinhold, K. J., Furman, P. A., St. Clair, M. H., Nusinoff-Lehrman, S., Gallo, R. C., Bolognesi, D., Barry, D. W. & Broder, S. (1985) Proc. Natl. Acad. Sci. USA 82, 7096-7100]. In contrast, inhibition of the growth of uninfected human fibroblasts and lymphocytes has been observed only at concentrations above 1 mM… 

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