Phosphorylation network dynamics in the control of cell cycle transitions.

  title={Phosphorylation network dynamics in the control of cell cycle transitions.},
  author={Daniel Fisher and Liliana Krasinska and Damien Coudreuse and B. Novak},
  journal={Journal of cell science},
  volume={125 Pt 20},
Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin - namely cyclin B - and cyclin dependent kinase 1 (Cdk1). When its activity is low, Cdk1 triggers the onset of S phase; when its activity level exceeds a specific threshold, it promotes entry into mitosis. This model has redefined our understanding of the essential functional inputs that organize cell cycle… CONTINUE READING
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