Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein.

@article{Eidenmller2001PhosphorylationmimickingGC,
  title={Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein.},
  author={Jochen Eidenm{\"u}ller and T Fath and Thomas Maas and Martin R Pool and Estelle Sontag and Roland Brandt},
  journal={The Biochemical journal},
  year={2001},
  volume={357 Pt 3},
  pages={759-67}
}
The microtubule-associated tau proteins represent a family of closely related phosphoproteins that become enriched in the axons during brain development. In Alzheimer's disease (AD), tau aggregates somatodendritically in paired helical filaments in a hyperphosphorylated form. Most of the sites that are phosphorylated to a high extent in paired helical filament tau are clustered in the proline-rich region (P-region; residues 172--251) and the C-terminal tail region (C-region; residues 368--441… CONTINUE READING
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