Phosphorylation-mediated negative regulation of RIG-I antiviral activity.

@article{Gack2010PhosphorylationmediatedNR,
  title={Phosphorylation-mediated negative regulation of RIG-I antiviral activity.},
  author={Michaela U Gack and Estanislao Nistal-Vill{\'a}n and Kyung-Soo Inn and Adolfo Garc{\'i}a-Sastre and Jae U Jung},
  journal={Journal of virology},
  year={2010},
  volume={84 7},
  pages={3220-9}
}
Recognition of invading viruses by the host is elicited by cellular sensors which trigger signaling cascades that lead to type I interferon (IFN) gene expression. Retinoic acid-inducible gene I (RIG-I) has emerged as a key receptor for the detection of viral RNA in the cytosol, inducing IFN-mediated innate immune responses to limit viral replication through its interaction with MAVS (also called IPS-1, CARDIF, or VISA). Upon the recognition of viral RNA, the Lys-172 residue of RIG-I undergoes… CONTINUE READING