Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy.

@article{Jilani2008PhosphorylationLO,
  title={Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy.},
  author={Iman B Jilani and Hagop M Kantarjian and Mercedes Gorre and Jorge E. Cortes and Oliver G Ottmann and Kapil Bhalla and Francis J Giles and Maher Albitar},
  journal={Leukemia research},
  year={2008},
  volume={32 4},
  pages={643-9}
}
Ex-vivo studies have suggested that imatinib-resistance in chronic myeloid leukemia (CML) patients occurs despite adequate suppression of BCR-ABL activity. Whether BCR-ABL phosphorylation levels differ between imatinib-sensitive and -resistant patients is not known. We compared the phosphorylation of BCR-ABL in 54 previously untreated CML patients and 62 imatinib-resistant CML patients with progressive disease. Resistant patients had significantly lower levels of BCR-ABL, CrkL and AKT… CONTINUE READING

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