Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.

@article{Srivastava2002PhosphorylationIR,
  title={Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.},
  author={Jyoti Srivastava and Katarzyna J. Procyk and Xavier Iturrioz and Peter J Parker},
  journal={The Biochemical journal},
  year={2002},
  volume={368 Pt 1},
  pages={
          349-55
        }
}
Classical and novel protein kinase C (PKC) isoforms are down-regulated as a result of chronic activation by certain tumour promoters and physiological stimuli; however, the mechanisms leading to down-regulation are not fully understood. In the present study, we have studied the PMA ('TPA')-induced degradation of PKCdelta in NIH 3T3 cells under culture conditions where PKCdelta displays cell-cycle-dependent down-regulation. In contrast with previous studies, a hyperphosphorylated form of this… CONTINUE READING
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