Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin.

@article{Torricelli2015PhosphorylationindependentMI,
  title={Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin.},
  author={Claudia Torricelli and Elena Daveri and Sara Salvadori and Giuseppe Valacchi and Francesca Ietta and Michela Muscettola and Filippo Carlucci and Emanuela Maioli},
  journal={Cancer letters},
  year={2015},
  volume={360 1},
  pages={17-27}
}
We recently found that Rottlerin not only inhibits proliferation but also causes Bcl-2- and Beclin 1-independent autophagic death in apoptosis-resistant breast adenocarcinoma MCF-7 cells. Having excluded a role for canonical signaling pathways, the current study was aimed to investigate the contribution of the AMPK/mTOR axis in autophagy induction and to search for the upstream signaling molecules potentially targeted by Rottlerin. Using several enzyme inhibitors, Western blotting analysis… CONTINUE READING
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