Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA.

@article{Sharf1997PhosphorylationEM,
  title={Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA.},
  author={Rakefet Sharf and David Meraro and Aviva Azriel and Angela M Thornton and Keiko Ozato and Emanual F. Petricoin and Andrew C Larner and Fred Schaper and Hansjoerg Hauser and Ben Zion Levi},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 15},
  pages={9785-92}
}
Two families of transcription factors mediate interferon (IFN) signaling. The first family, signal transducers and activators of transcription (STATs), is activated within minutes of IFN treatment. Specific phosphorylation events lead to their translocation to the nucleus, formation of transcriptional complexes, and the induction of the second family of transcription factors termed interferon regulatory factors (IRFs). Interferon consensus sequence binding protein (ICSBP) is a member of IRF… CONTINUE READING

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