Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.

@article{Bukrinskaya1996PhosphorylationdependentHI,
  title={Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.},
  author={Alice G. Bukrinskaya and Anuja Ghorpade and N K Heinzinger and Thomas E Smithgall and Russell E Lewis and Mario Stevenson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 1},
  pages={367-71}
}
In the replication of human immunodeficiency virus type 1 (HIV-1), gag MA (matrix), a major structural protein of the virus, carries out opposing targeting functions. During virus assembly, gag MA is cotranslationally myristoylated, a modification required for membrane targeting of gag polyproteins. During virus infection, however, gag MA, by virtue of a nuclear targeting signal at its N terminus, facilitates the nuclear localization of viral DNA and establishment of the provirus. We now show… CONTINUE READING

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