Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27.

  title={Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27.},
  author={Jaromir Vlach and Silke Hennecke and Bruno Amati},
  journal={The EMBO journal},
  volume={16 17},
The p27(Kip1) protein associates with G1-specific cyclin-CDK complexes and inhibits their catalytic activity. p27(Kip1) is regulated at various levels, including translation, degradation by the ubiquitin/proteasome pathway and non-covalent sequestration. Here, we describe point mutants of p27 deficient in their interaction with either cyclins (p27(c-)), CDKs (p27(k-)) or both (p27(ck-)), and demonstrate that each contact is critical for kinase inhibition and induction of G1 arrest. Through its… CONTINUE READING
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