Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis

  title={Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis},
  author={Xiubin Liang and Ana Carina da Paula and Zolt{\'a}n Boz{\'o}ky and Hui Zhang and Carol A. Bertrand and Kathryn W. Peters and Julie Deborah Forman-Kay and Raymond A Frizzell},
  booktitle={Molecular biology of the cell},
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP/protein kinase A (PKA)-regulated chloride channel whose phosphorylation controls anion secretion across epithelial cell apical membranes. We examined the hypothesis that cAMP/PKA stimulation regulates CFTR biogenesis posttranslationally, based on predicted 14-3-3 binding motifs within CFTR and forskolin-induced CFTR expression. The 14-3-3β, γ, and ε isoforms were expressed in airway cells and interacted with CFTR in… CONTINUE READING


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