Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium.

Abstract

Phosphorylation of the alpha-1 subunit of rat Na+,K(+)-ATPase by protein kinase C has been shown previously to decrease the activity of the enzyme in vitro. We have now undertaken an investigation of the mechanism by which this inhibition occurs. Analysis of the phosphorylation of recombinant glutathione S-transferase fusion proteins containing putative… (More)

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@article{Logvinenko1996PhosphorylationBP, title={Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium.}, author={N. S. Logvinenko and Irina Dulubova and Natalya U. Fedosova and Stefan Larsson and Angus C. Nairn and Martin Esmann and Paul Greengard and Anita C Aperia}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1996}, volume={93 17}, pages={9132-7} }