Phosphorylation by cdc2-CyclinB1 kinase releases cytoplasmic dynein from membranes.

@article{Addinall2001PhosphorylationBC,
  title={Phosphorylation by cdc2-CyclinB1 kinase releases cytoplasmic dynein from membranes.},
  author={Stephen G. Addinall and Petra S Mayr and Sukhjeevan Doyle and John Kieran Sheehan and Philip Woodman and Victoria J Allan},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 19},
  pages={15939-44}
}
Movement of various cargoes toward microtubule minus ends is driven by the microtubule motor cytoplasmic dynein (CD). Many cargoes are motile only during certain cell cycle phases, suggesting that CD function may be under cell cycle control. Phosphorylation of the CD light intermediate chain (DLIC) has been suggested to play a crucial role in modulating CD function during the Xenopus embryonic cell cycle, where CD-driven organelle movement is active in interphase but greatly reduced in… CONTINUE READING

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