Phosphorylation barcoding as a mechanism of directing GPCR signaling.

@article{Liggett2011PhosphorylationBA,
  title={Phosphorylation barcoding as a mechanism of directing GPCR signaling.},
  author={Stephen B. Liggett},
  journal={Science signaling},
  year={2011},
  volume={4 185},
  pages={pe36}
}
A unifying mechanism by which G protein-coupled receptors (GPCRs) signal in cell type-dependent and G protein-independent ways has developed over the past decade. GPCR kinases (GRKs) are mediators of homologous desensitization: GRK phosphorylation of the receptors leads to the subsequent binding of β-arrestins, which partially quenches receptor coupling to G proteins. For some receptors, this GRK-mediated phosphorylation stimulates additional signaling through the scaffolding action of… CONTINUE READING