Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants.

@article{Ramamoorthy1999PhosphorylationAS,
  title={Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants.},
  author={Sammanda Ramamoorthy and Randy D. Blakely},
  journal={Science},
  year={1999},
  volume={285 5428},
  pages={763-6}
}
Many psychotropic drugs interfere with the reuptake of dopamine, norepinephrine, and serotonin. Transport capacity is regulated by kinase-linked pathways, particularly those involving protein kinase C (PKC), resulting in transporter phosphorylation and sequestration. Phosphorylation and sequestration of the serotonin transporter (SERT) were substantially impacted by ligand occupancy. Ligands that can permeate the transporter, such as serotonin or the amphetamines, prevented PKC-dependent SERT… CONTINUE READING
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