Phosphorylation and regulation of Raf by Akt (protein kinase B).

@article{Zimmermann1999PhosphorylationAR,
  title={Phosphorylation and regulation of Raf by Akt (protein kinase B).},
  author={Stephanie Zimmermann and Karin Moelling},
  journal={Science},
  year={1999},
  volume={286 5445},
  pages={
          1741-4
        }
}
Activation of the protein kinase Raf can lead to opposing cellular responses such as proliferation, growth arrest, apoptosis, or differentiation. Akt (protein kinase B), a member of a different signaling pathway that also regulates these responses, interacted with Raf and phosphorylated this protein at a highly conserved serine residue in its regulatory domain in vivo. This phosphorylation of Raf by Akt inhibited activation of the Raf-MEK-ERK signaling pathway and shifted the cellular response… CONTINUE READING
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