Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin.

@article{Wang2013PhosphorylationAR,
  title={Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin.},
  author={Y X Rachel Wang and Roger H.F. Wong and Tianyi Tang and Carolyn S. S. Hudak and Di Yang and Robin E. Duncan and Hei Sook Sul},
  journal={Molecular cell},
  year={2013},
  volume={49 2},
  pages={283-97}
}
Fatty acid and triglyceride synthesis is induced in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of lipogenic enzymes, including fatty acid synthase and glycerol-3-phosphate acyltransferase. We recently reported the importance of USF-1 phosphorylation and subsequent acetylation in insulin-induced lipogenic gene activation. Here, we show that Brg1/Brm-associated factor (BAF) 60c is a specific chromatin remodeling component for lipogenic… CONTINUE READING
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