Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage.

@article{Anderson2001PhosphorylationAR,
  title={Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage.},
  author={Lorraine P. Anderson and Colin Henderson and Yuka Adachi},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 5},
  pages={1719-29}
}
53BP1 is a human BRCT protein that was originally identified as a p53-interacting protein by the Saccharomyces cerevisiae two-hybrid screen. Although the carboxyl-terminal BRCT domain shows similarity to Crb2, a DNA damage checkpoint protein in fission yeast, there is no evidence so far that implicates 53BP1 in the checkpoint. We have identified a Xenopus homologue of 53BP1 (XL53BP1). XL53BP1 is associated with chromatin and, in some cells, localized to a few large foci under normal conditions… CONTINUE READING