Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma.

@article{Liu2008PhosphorylationAN,
  title={Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma.},
  author={Yiping Liu and Yun-Nian Tan and Zhen-Lian Wang and Liang Zeng and Zhong-xin Lu and Li-li Li and Wei Luo and Min Tang and Ya Jun Cao},
  journal={International journal of molecular medicine},
  year={2008},
  volume={21 2},
  pages={153-62}
}
The Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) oncoprotein has been shown to mediate activation of the signal transducer and activator of transcription 3 (STAT3). In the present study, we delineated the mechanism by which LMP1 stimulates STAT3 in a human nasopharyngeal carcinoma (NPC) cell line. LMP1 stimulated STAT3 Tyr 705-dependent nuclear accumulation, as well as the phosphorylation of STAT3 at both Tyr 705 and Ser 727. Treatment of cells with interleukin-6 neutralizing… CONTINUE READING

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The STATs of cancer - new molecular targets come of age

  • RJ Hua Yu
  • Nat Rev Cancer
  • 2004
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