Phosphorylation and functions of inhibitor-2 family of proteins.

  title={Phosphorylation and functions of inhibitor-2 family of proteins.},
  author={Mingguang Li and David L. Satinover and David L. Brautigan},
  volume={46 9},
Protein phosphatase-1 (PP1) is an essential protein Ser/Thr phosphatase that is extraordinarily conserved from yeast to human, and Inhibitor-2 (I-2) is the most ancient of the heat-stable proteins specific for PP1. We identified novel I-2 homologues in Caenorhabditis elegans (Ce) and Xenopus laevis (Xe) and compared them to the I-2 proteins from Homo sapiens (Hs), Saccharomyces cerevisiae (GLC8), and Drosophila melanogaster (Dm). The Ce I-2 and Dm I-2 showed the highest potency inhibition of… CONTINUE READING


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