Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1.

@article{AvendaoVzquez2005PhosphorylationAD,
  title={Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1.},
  author={S. Er{\'e}ndira Avenda{\~n}o-V{\'a}zquez and Agust{\'i}n Garc{\'i}a-Caballero and J Adolfo Garc{\'i}a-S{\'a}inz},
  journal={The Biochemical journal},
  year={2005},
  volume={385 Pt 3},
  pages={
          677-84
        }
}
In C9 cells, LPA (lysophosphatidic acid) induced inositol phosphate production, increased intracellular calcium concentration and inhibited adenylate cyclase activity. These responses were abolished in cells challenged with active phorbol esters. Action of phorbol esters was blocked by inhibitors of PKC (protein kinase C) and by its down-regulation. LPA1 receptor phosphorylation was observed in response to phorbol esters. The effect was rapid (t1/2 approximately 1 min), intense (2-fold) and… CONTINUE READING

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