Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase.

@article{Richardson1993PhosphorylationAD,
  title={Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase.},
  author={Ricardo Micheler Richardson and Chul Min Kim and Jeffrey L. Benovic and M. Marlene Hosey},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 18},
  pages={13650-6}
}
Studies of the human m2 (hm2) muscarinic cholinergic receptors (mAChR) have been performed to provide further insights into the potential regulation of these receptors by isoforms of the beta-adrenergic receptor kinase (beta ARK). The hm2 mAChR and the isoforms beta ARK1 and beta ARK2 were individually expressed in, and purified from, insect Sf9 cells infected with recombinant baculoviruses. The expressed hm2 receptors were tested as substrates for beta ARK1 and beta ARK2 in vitro using… CONTINUE READING