Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin

@article{Dou2002PhosphorylationAA,
  title={Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin},
  author={Y. Dou and J. Bowen and Y. Liu and M. Gorovsky},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={158},
  pages={1161 - 1170}
}
  • Y. Dou, J. Bowen, +1 author M. Gorovsky
  • Published 2002
  • Medicine, Biology
  • The Journal of Cell Biology
  • In Tetrahymena cells, phosphorylation of linker histone H1 regulates transcription of specific genes. Phosphorylation acts by creating a localized negative charge patch and phenocopies the loss of H1 from chromatin, suggesting that it affects transcription by regulating the dissociation of H1 from chromatin. To test this hypothesis, we used FRAP of GFP-tagged H1 to analyze the effects of mutations that either eliminate or mimic phosphorylation on the binding of H1 to chromatin both in vivo and… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 81 REFERENCES
    Phosphorylation of linker histone H1 regulates gene expression in vivo by creating a charge patch.
    94
    Phosphorylation of linker histone H1 regulates gene expression in vivo by mimicking H1 removal.
    132
    Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes
    169
    Mitotic Phosphorylation Prevents the Binding of HMGN Proteins to Chromatin
    69
    Chromatin condensation: does histone H1 dephosphorylation play a role?
    176
    Linker Histone H1 Regulates Specific Gene Expression but Not Global Transcription In Vivo
    271
    Dynamic binding of histone H1 to chromatin in living cells
    570