Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin

@article{Dou2002PhosphorylationAA,
  title={Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin},
  author={Yali Dou and J. K. Bowen and Yifan Liu and M. A. Gorovsky},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={158},
  pages={1161 - 1170}
}
In Tetrahymena cells, phosphorylation of linker histone H1 regulates transcription of specific genes. Phosphorylation acts by creating a localized negative charge patch and phenocopies the loss of H1 from chromatin, suggesting that it affects transcription by regulating the dissociation of H1 from chromatin. To test this hypothesis, we used FRAP of GFP… CONTINUE READING