Phosphorylation and activation of brain aromatic L-amino acid decarboxylase by cyclic AMP-dependent protein kinase.

@article{Duchemin2000PhosphorylationAA,
  title={Phosphorylation and activation of brain aromatic L-amino acid decarboxylase by cyclic AMP-dependent protein kinase.},
  author={A M Duchemin and Mark D Berry and Norton H. Neff and Maria Hadjiconstantinou},
  journal={Journal of neurochemistry},
  year={2000},
  volume={75 2},
  pages={725-31}
}
Aromatic L-amino acid decarboxylase (AAAD), an enzyme required for the synthesis of catecholamines, indoleamines, and trace amines, is rapidly activated by cyclic AMP-dependent pathways in striatum and midbrain in vivo, suggesting enzyme phosphorylation. We now report that the catalytic subunit of cyclic AMP-dependent protein kinase (PKA) directly phosphorylated AAAD immunoprecipitated from homogenates prepared from the mouse striatum and midbrain in vitro. Under the same phosphorylation… CONTINUE READING

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