Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

  title={Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex},
  author={D. Sarbassov and D. Guertin and S. Ali and D. Sabatini},
  pages={1098 - 1101}
  • D. Sarbassov, D. Guertin, +1 author D. Sabatini
  • Published 2005
  • Medicine
  • Science
  • Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by the phosphoinositide-dependent kinase 1 (PDK1) and Ser473 within the carboxyl-terminal hydrophobic motif by an unknown kinase. We show that in Drosophila and human cells the target of rapamycin (TOR) kinase and its associated protein rictor are necessary for Ser473 phosphorylation and that a reduction in rictor… CONTINUE READING
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