Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

@article{Sarbassov2005PhosphorylationAR,
  title={Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex},
  author={D. Sarbassov and D. Guertin and S. Ali and D. Sabatini},
  journal={Science},
  year={2005},
  volume={307},
  pages={1098 - 1101}
}
  • D. Sarbassov, D. Guertin, +1 author D. Sabatini
  • Published 2005
  • Medicine
  • Science
  • Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by the phosphoinositide-dependent kinase 1 (PDK1) and Ser473 within the carboxyl-terminal hydrophobic motif by an unknown kinase. We show that in Drosophila and human cells the target of rapamycin (TOR) kinase and its associated protein rictor are necessary for Ser473 phosphorylation and that a reduction in rictor… CONTINUE READING
    4,343 Citations
    Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2
    • 69
    • PDF
    Rictor is a novel target of p70 S6 kinase-1
    • 153
    • PDF
    Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in β1 Integrin-Mediated Cell Survival
    • 46
    • Highly Influenced
    • PDF
    mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s
    • 625
    • PDF
    IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation
    • 180
    • PDF
    SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
    • 1,264
    • Highly Influenced
    • PDF
    Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth.
    • 132
    • PDF
    Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition
    • 130
    • PDF
    Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
    • 541
    • PDF

    References

    SHOWING 1-10 OF 51 REFERENCES
    Immunity
    • 1,032
    St. Jude Children's Research Hospital.
    • C. Pratt
    • Medicine
    • Pediatric hematology and oncology
    • 1997
    • 226
    • PDF
    References and Notes
    • 3,247
    • PDF
    • 2004
    • 1999
    • 2001
    Annu. Rev. Cell Dev. Biol
    • Annu. Rev. Cell Dev. Biol
    • 2002
    Biochim. Biophys. Acta
    • Biochim. Biophys. Acta
    • 2003