Phosphorylation affects voltage gating of the delayed rectifier K+ channel by electrostatic interactions.

@article{Perozo1990PhosphorylationAV,
  title={Phosphorylation affects voltage gating of the delayed rectifier K+ channel by electrostatic interactions.},
  author={Eduardo Perozo and Francisco Bezanilla},
  journal={Neuron},
  year={1990},
  volume={5 5},
  pages={685-90}
}
The delayed rectifier K+ channel of the squid axon undergoes a series of modifications in its kinetic and conductive parameters when it is phosphorylated as the result of shifts in its voltage-dependent parameters. These effects can be interpreted as due to electrostatic interaction between the voltage sensor of the channel and the transferred phosphate from ATP. Using different concentrations of intracellular Mg2+, we determined the density of surface charges seen by the K+ channel voltage… CONTINUE READING

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