Phosphorylation State Defines Discrete Roles for Monopolin in Chromosome Attachment and Spindle Elongation

@article{Choi2009PhosphorylationSD,
  title={Phosphorylation State Defines Discrete Roles for Monopolin in Chromosome Attachment and Spindle Elongation},
  author={Sung Hugh Choi and Marie-Pierre P{\'e}li-Gulli and Iain McLeod and Ali Sarkeshik and John R. Yates and Viesturs Simanis and Dannel McCollum},
  journal={Current Biology},
  year={2009},
  volume={19},
  pages={985-995}
}
BACKGROUND It is unknown how oscillations in Cdk1 activity drive the dramatic changes in chromosome and spindle dynamics that occur at the metaphase/anaphase transition. RESULTS We show that the Schizosaccharomyces pombe monopolin complex has distinct functions in metaphase and anaphase that are determined by the phosphorylation state of its Mde4 subunit. When Cdk1 activity is high in metaphase, Mde4 is hyperphosphorylated on Cdk1 phosphorylation sites and localizes to kinetochores. A… CONTINUE READING

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