Phosphorylation State, Solubility, and Activity of Calcium/Calmodulin-Dependent Protein Kinase IIα in Transient Focal Ischemia in Mouse Brain

Abstract

During and after middle cerebral artery occlusion in mice, CaMKIIα protein was irreversibly translocated from the soluble to the Triton X-100–nonsoluble fraction. This decrease in solubility had a strong effect on activity: CaMKIIα was almost completely inactivated after being translocated. Results from solubilization experiments suggest that different… (More)
DOI: 10.1023/A:1019844518704

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