Phosphorylation-Independent Regulation of the Diguanylate Cyclase WspR

@article{De2008PhosphorylationIndependentRO,
  title={Phosphorylation-Independent Regulation of the Diguanylate Cyclase WspR},
  author={Nabanita De and Michelle Pirruccello and Petya Violinova Krasteva and Narae Bae and Rahul Veera Raghavan and Holger Sondermann},
  journal={PLoS Biology},
  year={2008},
  volume={6},
  pages={183 - 215}
}
Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second messenger. Tight regulation of cellular c-di-GMP concentration is governed by diguanylate cyclases and phosphodiesterases, which are responsible for its production and degradation, respectively. Here, we present the crystal structure of the diguanylate cyclase WspR, a conserved GGDEF domain… CONTINUE READING

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