Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders.

  title={Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders.},
  author={Lidia Glodzik and Susan de Santi and Wai Hon Tsui and Lisa Mosconi and Raymond P Zinkowski and Elizabeth Pirraglia and Hui Wang and Yi Li and Kenneth E Rich and Henrik Zetterberg and K Blennow and Pankaj D. Mehta and Mony J de Leon},
  journal={Neurobiology of aging},
  volume={32 12},
Little is known whether cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) can predict both memory decline and associated longitudinal medial temporal lobe (MTL) gray matter (GM) reductions in cognitively healthy individuals. Fifty-seven normal elderly subjects received comprehensive evaluation at baseline and 2 years later. The baseline phosphorylated tau(231) (p-tau(231)), total tau, the amyloid beta (Aβ) Aβ42/Aβ40, t-tau/Aβ42 and p-tau(231)/Aβ42 ratios were examined as… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association • 2015
View 1 Excerpt

Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 1 Excerpt

Tau Phosphorylation by GSK3 in Different Conditions

International journal of Alzheimer's disease • 2012

Similar Papers

Loading similar papers…