Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders.

@article{Glodzik2011PhosphorylatedT2,
  title={Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders.},
  author={Lidia Glodzik and Susan de Santi and Wai Hon Tsui and Lisa Mosconi and Raymond P Zinkowski and Elizabeth Pirraglia and Hui Wang and Yi Li and Kenneth E Rich and Henrik Zetterberg and K Blennow and Pankaj D. Mehta and Mony J de Leon},
  journal={Neurobiology of aging},
  year={2011},
  volume={32 12},
  pages={2131-41}
}
Little is known whether cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) can predict both memory decline and associated longitudinal medial temporal lobe (MTL) gray matter (GM) reductions in cognitively healthy individuals. Fifty-seven normal elderly subjects received comprehensive evaluation at baseline and 2 years later. The baseline phosphorylated tau(231) (p-tau(231)), total tau, the amyloid beta (Aβ) Aβ42/Aβ40, t-tau/Aβ42 and p-tau(231)/Aβ42 ratios were examined as… CONTINUE READING

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