Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.

@article{Ferrer2001PhosphorylatedMK,
  title={Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.},
  author={Isidro Ferrer and Rosa M Blanco and Margarita Carmona and R L Ribera and E. Goutan and Berta Puig and Mar{\'i}a Jes{\'u}s Rey and Adriana V Cardozo and Francesc Vi{\~n}als and Teresa Ribalta},
  journal={Brain pathology},
  year={2001},
  volume={11 2},
  pages={144-58}
}
Abnormal tau phosphorylation and deposition in neurones and glial cells is one of the major features in taupathies. The present study examines the involvement of the Ras/MEK/ERK pathway of tau phosphorylation in Alzheimer disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), by Western blotting, single and double-labelling immunohistochemistry, and p21Ras activation assay. Since this pathway is also activated in several paradigms of cell… CONTINUE READING

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