Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy.

@article{Arai2010PhosphorylatedAC,
  title={Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy.},
  author={Tetsuaki Arai and Masato Hasegawa and Takashi Nonoka and Fuyuki Kametani and Makiko Yamashita and Masato Hosokawa and Kazuhiro Niizato and Kuniaki Tsuchiya and Zen Kobayashi and Kenji Ikeda and Mari Yoshida and Mitsumoto Onaya and Hiroshige Fujishiro and Haruhiko Akiyama},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  year={2010},
  volume={30 2},
  pages={170-81}
}
Transactivation response (TAR) DNA-binding protein of Mr 43 kDa (TDP-43) is a major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration which is now referred to as FTLD-TDP. Concurrent TDP-43 pathology has been reported in a variety of other neurodegenerative disorders such as Alzheimer's disease, forming a group of TDP-43 proteinopathy. Accumulated TDP-43 is characterized by phosphorylation… CONTINUE READING
34 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…