Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.

  title={Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.},
  author={Masato Hasegawa and Hideo Fujiwara and Takashi Nonaka and Koichi Wakabayashi and Hitoshi Takahashi and Virginia M-Y Lee and John Q. Trojanowski and David N Mann and Takeshi Iwatsubo},
  journal={The Journal of biological chemistry},
  volume={277 50},
alpha-Synuclein is one of the major components of intracellular fibrillary aggregates in the brains of a subset of neurodegenerative disorders, including Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and Hallervorden-Spatz disease, which are referred to as alpha-synucleinopathies. We have shown previously (Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and Iwatsubo, T. (2002) Nat. Cell Biol. 4, 160-164) that… CONTINUE READING
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