Phosphorylated Ser/Arg-rich proteins: limiting factors in the assembly of 200S large nuclear ribonucleoprotein particles.

@article{Yitzhaki1996PhosphorylatedSP,
  title={Phosphorylated Ser/Arg-rich proteins: limiting factors in the assembly of 200S large nuclear ribonucleoprotein particles.},
  author={S Yitzhaki and Elana Miriami and R. Sperling and Joseph Sperling},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 17},
  pages={8830-5}
}
We have previously shown that specific nuclear pre-mRNA transcripts and their splicing products, as well as the general population of nuclear poly(A)+ RNA, are packaged in large nuclear ribonucleoprotein (InRNP) particles that sediment at the 200S region in sucrose gradients. The InRNP particles contain all uridine-rich small nuclear ribonucleoprotein complexes required for pre-mRNA splicing, as well as protein splicing factors. In this paper we show that all of the phosphorylated, mAb 104… CONTINUE READING