Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma.

  • Hiroshi Aoki, Tomohisa Yokoyama, +8 authors Yasuko Kondo
  • Published 2007 in
    Clinical cancer research : an official journal of…
PURPOSE Glioblastoma is the most common primary malignant tumor in the brain. It aggressively invades the surrounding parenchyma, often allowing the tumor to progress after surgery. Accumulating evidence has shown that phosphorylated p21-activated kinase 1 (Pak1), a mediator of small guanosine triphosphatases, plays a role in the proliferation, survival… (More)