Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology


Down-regulation of protein phosphatase 2A (PP2A) is thought to play a critical role in tau hyperphosphorylation in Alzheimer's disease (AD). In vitro phosphorylation of PP2A catalytic subunit at Y307 efficiently inactivates PP2A. A specific antibody against phosphorylated (p) PP2A (Y307) (PP2Ac-Yp307) was used to investigate possible PP2A down-regulation by… (More)
DOI: 10.1111/j.1582-4934.2008.00249.x


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