Phosphorylated GSK3beta-ser9 and EGFR are good prognostic factors for lung carcinomas.

@article{Zheng2007PhosphorylatedGA,
  title={Phosphorylated GSK3beta-ser9 and EGFR are good prognostic factors for lung carcinomas.},
  author={Huachuan Zheng and Hiroshi Yokohama-shi Saito and Shinji Masuda and Xianghong Yang and Yasuo Takano},
  journal={Anticancer research},
  year={2007},
  volume={27 5B},
  pages={
          3561-9
        }
}
BACKGROUND Glycogen synthase kinase-3beta (GSK3beta), serine/threonine protein kinase, has been reported to repress the Wnt/beta-catenin pathway and regulate the balance between cellular proliferation and apoptosis. Epithelial growth factor receptor (EGFR) might phosphorylate GSK3beta into inactive phosphorylated GSK3beta-ser9 (P-GSK3beta-ser9). PATIENTS AND METHODS P-GSK3beta-ser9 and EGFR expressions were examined on tissue microarrays (TMA) of lung carcinoma (n=154) by immunohistochemistry… CONTINUE READING

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