Phosphorylated CpxR Restricts Production of the RovA Global Regulator in Yersinia pseudotuberculosis

@inproceedings{Liu2011PhosphorylatedCR,
  title={Phosphorylated CpxR Restricts Production of the RovA Global Regulator in Yersinia pseudotuberculosis},
  author={Junfa Liu and Ikenna R. Obi and Edvin J. Thanikkal and Thomas Kieselbach and Matthew S. Francis},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND RovA is a global transcriptional regulator of gene expression in pathogenic Yersinia. RovA levels are kept in check by a sophisticated layering of distinct transcriptional and post-transcriptional regulatory mechanisms. In the enteropathogen Y. pseudotuberculosis, we have previously reported that the extracytoplasmic stress sensing CpxA-CpxR two-component regulatory system modulates rovA expression. METHODOLOGY/PRINCIPAL FINDINGS In this study, we characterized CpxR phosphorylation… CONTINUE READING