Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia.

@article{Konoplev2011PhosphorylatedCI,
  title={Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia.},
  author={Sergej N Konoplev and Jeffrey L. Jorgensen and Deborah A. Thomas and Erpei Lin and Jan Burger and Hagop M Kantarjian and Michael Andreeff and L Jeffrey Medeiros and Marina Y Konopleva},
  journal={Cancer},
  year={2011},
  volume={117 20},
  pages={4689-95}
}
BACKGROUND CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation (pCXCR4) and is essential for the migration of hematopoietic precursors to bone marrow. CXCR4 overexpression predicts a poor prognosis in patients with acute myeloid leukemia. Data regarding the prognostic impact of CXCR4 in patients with B-acute lymphoblastic leukemia (B-ALL) are sparse and limited to the pediatric population. METHODS The authors analyzed CXCR4 and pCXCR4 expression in 54 adults with newly diagnosed… CONTINUE READING

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