Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.

@article{FunakoshiTago2017PhosphorylatedCS,
  title={Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.},
  author={Megumi Funakoshi-Tago and Takuro Moriwaki and Fumihito Ueda and Hiroomi Tamura and Tadashi Kasahara and Kenji Tago},
  journal={Cellular signalling},
  year={2017},
  volume={31},
  pages={
          41-57
        }
}
The JAK2 V617F mutant-mediated aberrant signaling pathway is a hallmark of myeloproliferative neoplasms (MPNs). Although cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are negative regulators of the JAK-STAT pathway, the functional role of CIS/SOCS family members in the JAK2 V617F mutant-induced oncogenic signaling pathway has not yet been elucidated. In this study, we found that the expression of CIS and SOCS1 was induced through the activation of… CONTINUE READING

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