Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.

@article{FunakoshiTago2017PhosphorylatedCS,
  title={Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.},
  author={Megumi Funakoshi-Tago and Takuro Moriwaki and Fumihito Ueda and Hiroomi Tamura and Tadashi Kasahara and Kenji Tago},
  journal={Cellular signalling},
  year={2017},
  volume={31},
  pages={
          41-57
        }
}
  • Megumi Funakoshi-Tago, Takuro Moriwaki, +3 authors Kenji Tago
  • Published 2017
  • Medicine, Biology
  • Cellular signalling
  • The JAK2 V617F mutant-mediated aberrant signaling pathway is a hallmark of myeloproliferative neoplasms (MPNs). Although cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are negative regulators of the JAK-STAT pathway, the functional role of CIS/SOCS family members in the JAK2 V617F mutant-induced oncogenic signaling pathway has not yet been elucidated. In this study, we found that the expression of CIS and SOCS1 was induced through the activation of… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 52 REFERENCES

    SOCS2: inhibitor of JAK2V617F-mediated signal transduction

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL