Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer.


BACKGROUND Growth factor receptors and cell signaling factors play a crucial role in human carcinomas and have been studied in ovarian tumors with varying results. Cell signaling involves multiple pathways and a myriad of factors that can be mutated or amplified. Cell signaling is driven through the mammalian target of rapamycin (mTOR) and extracellular… (More)